Endocrine Abstracts

Background: Polycystic ovary syndrome (PCOS) is associated with obesity and low grade inflammation, factors linked to cardiovascular disease (CVD).Methods: National Register-based study including women with PCOS and no previous diagnosis of CVD or hypertension. PCOS OUH (n=1165) included premenopausal women with PCOS and clinical and biochemical examination. PCOS Denmark (n=18 112) included women with PCOS in the Danish National Patient...

Introduction: Maintenance immunosuppressive regimens after renal transplantation (RTx) most often include prednisolone which may induce secondary adrenal insufficiency. Adrenal insufficiency is a potentially life-threatening side effect to glucocorticoid treatment due to the risk of acute adrenal crisis. We aimed to investigate the prevalence of prednisolone-induced adrenal insufficiency in RTx patients receiving long-term low-dose prednisolone treatment.<p class="abstext"...

Background: Thyroid incidentaloma are asymptomatic thyroid nodules that are discovered on an imaging study performed to evaluate other structures. Clinically unrecognized thyroid nodules are common and can be found in up to 50–60% of patients at autopsy.1 Increased use of imaging modalities of better quality in the modern era has resulted in an increased detection of incidental thyroid nodules. The prevalence rate is 67% with ultrasonography (US) imaging, 15% w...

IntroductionPatients with pituitary adenomas undergoing transsphenoidal surgery require pre- and post-surgery examination of pituitary hormones. There is currently no consensus on how to evaluate the adrenal axis post-surgery. The aims of this study were to investigate factors that may predict postoperative adrenal insufficiency (AI) and to investigate the overall effect of transsphenoidal surgery on the pituitary function.Methods<...

Background: Perfluoroalkyl substances (PFAS) are endocrine disrupting chemicals, with elimination half-lives ranging from four to eight years. Experimental studies indicate that PFAS may disrupt androgenic and estrogenic pathways, potentially affecting fetal development. During 1st trimester, concentrations of sex hormone-binding globulin (SHBG) increase due to higher estrogen levels from the placenta. The increment of SHBG concentration results in a compensatory increase in t...

Background: Maternal cortisol levels increase during pregnancy and prenatal cortisol exposure have been linked to cognitive function in childhood. Higher activity of the enzyme 11β-hydroxysteroid-dehydrogenase type 2 (11β-HSD2) downregulates the amount of maternal cortisol crossing the placenta by inactivation of cortisol to cortisone. In childhood, boys perform significantly poorer in tests of intelligence than girls.Aim: To investigate associ...

Adrenal hormones possess both circadian and ultradian rhythms, making interpretation of single time point measurements difficult, particularly in the context of suspected endocrine disease. Attempting to capture either normal or pathological rhythms in detail by traditional measurement of blood is impractical and generally unfeasible. However, minimally invasive microdialysis sampling of free tissue hormones coupled with a portable fraction collector (U-RHYTHM), and a targeted...

Background: Recently, we have shown that ambulatory 24-hour dynamic steroid profiling using the newly developed U-RHYTHM system is possible and presented the circadian and ultradian rhythmicity of adrenal hormones in a healthy cohort. With U-RHYTHM, multiple hormones can be sampled simultaneously, and the free active hormones can be measured in local tissue where the effect is exerted. Thus the hormone fingerprint resulting from replacement therapy in individual patients can b...

Background: Gender affirming hormonal treatment (GAHT) is for many a cornerstone of transgender care. National data regarding use of hormonal treatment by transgender persons are limited.Aim: To assess use of GAHT in transgender persons.Design: National register-based cohort study in Danish transgender persons followed from 2000 until 2018. The main outcome measure was redemption of GAHT. Persons with an ICD-10 diagnosis code of &#...

Background: Language development during early childhood is considered an important marker of fetal neurodevelopment. Prenatal cortisol exposure plays a critical role in maturation of the fetal brain; however, the effect on offspring language development needs further investigation. This study aimed to evaluate the association between maternal 3rd trimester cortisol and early longitudinal offspring language development and to test whether there was sex differences in...